1980: The League began plans for the development of The Children’s Museum of Pittsburgh. The actual opening was fall of 1981.
1982 – 1983: The League helped to staff Bright Beginnings Warm Line, a parental stress center to help prevent the occurrence of child abuse.
1983: The League assisted Pittsburgh City Council with bringing the US Figure Skating Championships to the Civic Arena.
1984: 244 North Bellefield Ave in Oakland was purchased as the new League head quarters. The League rented space in the building for meetings, banquets, and special events.
1985: The League helps to start Second Chance, a nonprofit kinship foster care agency.
1986: The League and the transplant center at the University of Pittsburgh spearheaded a task force that determined that Transplant Recipients International Organization (TRIO) could best serve more people through an international, independent parent organization with local chapters worldwide. To achieve this goal, in 1987, TRIO was incorporated as a nonprofit organization. The original group of TRIO members became the Pittsburgh chapter, the founding chapter of TRIO.
1987: The League started Teen Outreach programs to help combat teenage pregnancy and drop out among high school students.
1987 – 1988: The League participated with the United Way project, BoardWALK, which helped to identify, recruit, and connect volunteers to leadership and policy making positions in nonprofit organizations.
1989 - 1990: The League cosponsored Shakespeare Saved, a cultural literacy program.
1989 – 1990: The League sponsored Woman to Woman, an alcohol abuse and awareness program.